MicroRNA-224: as a potential target for miR-based therapy of cancer

被引：20
作者：
Chen, Wei [1 ,2 ]
Fan, Xue-mei [3 ]
Mao, Ling [4 ]
Zhang, Jun-ying [2 ]
L, Jian, I [2 ]
Wu, Jian-zhong [2 ]
Tang, Jin-hai [2 ,5 ]
机构：
[1] Xuzhou Med Coll, Grad Sch, Xuzhou, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Canc Hosp, Canc Inst Jiangsu Prov, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Matern & Child Hlth Care Hosp, Nanjing, Jiangsu, Peoples R China
[4] Huaian Second Peoples Hosp, Dept Gen Surg, Huaian, Peoples R China
[5] Nanjing Med Univ, Affiliated Jiangsu Canc Hosp, Dept Gen Surg, Nanjing 210000, Jiangsu, Peoples R China
来源：
TUMOR BIOLOGY | 2015年 / 36卷 / 09期
基金：
中国国家自然科学基金;
关键词：
MicroRNA; MicroRNA-224; Cancer; Therapy; Biomaker; HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; UP-REGULATION; COLORECTAL-CANCER; MIR-224; PROMOTES; PROSTATE-CANCER; POOR-PROGNOSIS; TUMOR-GROWTH; EXPRESSION; INVASION;
D O I：
10.1007/s13277-015-3883-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) are small noncoding RNA molecules which regulate the target gene expression posttranscriptionally. Increasing studies have shown that microRNAs play important roles in multiple biological pathways. For instance, aberrant expression of microRNA-224 (miR-224) plays a vital role in tumor biology in various types of human cancer. Here, we aim to summarize the molecular mechanisms that lead to the overexpression of miR-224 in cancers, analyze the effect of miR-224 on tumor biology, and reveal the clinical significance of miR-224. MiR-224 regulates its targets by modulating messenger RNA (mRNA) stability and/or protein translation, and it would provide new insight into molecular targeting cancer treatment.
引用
收藏
页码：6645 / 6652
页数：8
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