In vivo accumulation of nitric oxide in blood vessels

被引：9

作者：

Smirin, BV

Vanin, AF

Malyshev, IY

Pokidyshev, DA

Manukhina, EB

机构：

[1] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow, Russia

[2] Russian Acad Sci, Inst Chem Phys, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 127卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

nitric oxide; nitric oxide stores; dinitrosyl iron complex; adaptation to stress;

D O I：

10.1007/BF02433280

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Against the background of NO-synthase blockade, diethyldithiocarbamate had no effect on the tone of isolated rat aorta, but induced relaxation of aorta preparations isolated after in vivo NO accumulation and isolated aorta incubated with dinitrosyl iron complex. Guanylate cyclase inhibitor methylene blue prevented the relaxation induced by diethyldithiocarbamate. These data suggest that accumulation of NO in the organism can result in its accumulation in the vessel wall. in the vessel wall.

引用

页码：571 / 574

页数：4

共 14 条

[1] FEEDBACK INHIBITION OF NITRIC-OXIDE SYNTHASE ACTIVITY BY NITRIC-OXIDE [J].