Hypersensitivity pneumonitis in a cluster of sawmill workers: a 10-year follow-up of exposure, symptoms, and lung function

被引:19
作者
Faerden, Karl [1 ]
Lund, May Brit [2 ,3 ]
Aalokken, Trond Mogens [4 ]
Eduard, Wijnand [5 ]
Sostrand, Per [1 ]
Langard, Sverre [1 ]
Kongerud, Johny [2 ,3 ]
机构
[1] Oslo Univ Hosp, Dept Environm & Occupat Med, Oslo, Norway
[2] Oslo Univ Hosp, Rikshosp, Dept Resp Med, Oslo, Norway
[3] Univ Oslo, Fac Med, N-0316 Oslo, Norway
[4] Oslo Univ Hosp, Dept Radiol, Oslo, Norway
[5] Natl Inst Occupat Hlth, Oslo, Norway
关键词
Hypersensitivity pneumonitis; Sawmills; Mold spore exposure; Lung function; HRCT scan; Prognosis; FARMERS LUNG; RESPIRATORY SYMPTOMS; ALLERGIC ALVEOLITIS; PULMONARY-FUNCTION; ANTIBODIES; SPORES;
D O I
10.1179/2049396714Y.0000000063
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: The long-term prognosis of repeated acute episodes of hypersensitivity pneumonitis (HP) is not well described. We report on a 10-year follow-up of a 10-person cluster from a Norwegian sawmill who had all experienced relapsing episodes of HP. Objectives: To evaluate the health symptoms, work-related sick-leave, and lung function of 10 workers exposed to mold in a Norwegian sawmill. Methods: Participants were evaluated at baseline and 10 years later at follow-up. A structured interview, measurement of serum IgG antibodies to Rhizopus microsporus (R. microsporus) antigens, lung function tests, high resolution computed tomography (HRCT) of the chest, and personal measurements of exposure to mold spores and dust were completed for each participant. Results: At baseline, nearly all workers reported acute episodes of HP more than twice a month. At follow-up, both the frequency and intensity of symptoms had declined. Sick-leave was reduced and gas diffusing capacity improved - paralleling the gradually reduced air levels of mold spores. Conclusions: In spite of an initially high occurrence of symptoms, long-term clinical and physiological outcome was good. With reduced exposure to mold spores, symptoms declined and lung function was restored.
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页码:167 / 173
页数:7
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