Acute myeloid leukemia cells harboring MLL fusion genes or with the acute promyelocytic leukemia phenotype are sensitive to the Bcl-2-selective inhibitor ABT-199

被引:95
作者
Niu, X. [1 ]
Wang, G. [1 ,2 ]
Wang, Y. [3 ]
Caldwel, J. T. [4 ,5 ]
Edwards, H. [6 ,7 ]
Xie, C. [1 ,6 ,7 ]
Taub, J. W. [2 ,7 ,8 ]
Li, C.
Lin, H. [9 ]
Ge, Y. [1 ,6 ,7 ]
机构
[1] Jilin Univ, Sch Life Sci, Natl Engn Lab AIDS Vaccine, Key Lab Mol Enzymol & Engn,Minist Educ, Changchun 130023, Peoples R China
[2] Wayne State Univ, Sch Med, Dept Pediat, Detroit, MI 48201 USA
[3] Jilin Univ, Hosp 1, Dept Pediat Hematol & Oncol, Changchun 130023, Peoples R China
[4] Wayne State Univ, Sch Med, Detroit, MI USA
[5] Wayne State Univ, Sch Med, Canc Biol Grad Program, Detroit, MI USA
[6] Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI USA
[7] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Mol Therapeut Program, Detroit, MI USA
[8] Childrens Hosp Michigan, Div Pediat Hematol Oncol, Detroit, MI 48201 USA
[9] Jilin Univ, Hosp 1, Dept Hematol & Oncol, Changchun 130023, Peoples R China
关键词
THERAPY; CANCER;
D O I
10.1038/leu.2014.72
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1557 / 1560
页数:4
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