Polymorphism and Solvatomorphism 2007

Papers and patents that deal with polymorphism (crystal systems for which a substance can exist in structures characterized by different unit cells, but where each of the forms has exactly the same elemental composition) and solvatomorphism, (systems where the crystal structures of the substance are defined by different unit cells, but where these unit cells differ in their elemental composition through the inclusion of one or molecules of solvent) have been summarized ill an annual review. The works cited in this review were published during 2007, and were drawn from the major physical, crystallographic, and pharmaceutical Journals. The review is divided into sections that cover articles of general interest, computational and theoretical studies, preparative and isolation methods, structural characterization and properties of polymorphic and solvatomorphic systems, studies of phase transformations, effects associated with secondary processing, and United States patents issued during 2007. (c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:1617-1642, 2009