Histological transformation from non-small cell to small cell lung carcinoma after treatment with epidermal growth factor receptor-tyrosine kinase inhibitor

被引：30

作者：

Kim, Woo-Jin ^{[1
,2
]}

Kim, Sunmin ^{[1
]}

Choi, Hayoung ^{[1
]}

Chang, Jinsun ^{[1
]}

Shin, Hong-Joon ^{[1
,2
]}

Park, Cheol-Kyu ^{[1
,2
]}

Oh, In-Jae ^{[1
,2
]}

Kim, Kyu-Sik ^{[1
,2
]}

Kim, Young-Chul ^{[1
,2
]}

Choi, Yoo-Duk ^{[2
,3
]}

机构：

[1] Chonnam Natl Univ, Sch Med, Dept Internal Med, Gwangju, South Korea

[2] Chonnam Natl Univ, Hwasun Hosp, Lung & Esophageal Canc Clin, Jeonnam, South Korea

[3] Chonnam Natl Univ, Sch Med, Dept Pathol, Gwangju, South Korea

来源：

THORACIC CANCER | 2015年 / 6卷 / 06期

关键词：

Drug resistance; epidermal growth factor receptor; small cell carcinoma; transformation; EGFR MUTATION; CANCER; ADENOCARCINOMA; RESISTANCE;

D O I：

10.1111/1759-7714.12217

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several cases of acquired resistance in patients with activating epidermal growth factor receptor (EGFR) mutation have been reported. However, rare clinical cases exist of a transformation to small cell lung cancer (SCLC) following treatment with EGFR-tyrosine kinase inhibitors (TKIs). We report a case of non-small cell lung cancer (NSCLC) with L858R mutation at the time of diagnosis. After failure of EGFR-TKI therapy, we performed additional histopathologic examinations. We confirmed that the patient had a histological transformation from NSCLC to SCLC. We performed chemotherapy with etoposide and cisplatin against the SCLC and radiologic findings were improved.

引用

页码：800 / 804

页数：5

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