Adverse prognostic effect of homozygous TET2 mutation on the relapse risk of acute myeloid leukemia in patients of normal karyotype

被引：31

作者：

Ahn, Jae-Sook ^{[1
]}

Kim, Hyeoung-Joon ^{[1
]}

Kim, Yeo-Kyeoung ^{[1
]}

Jung, Sung-Hoon ^{[1
]}

Yang, Deok-Hwan ^{[1
]}

Lee, Je-Jung ^{[1
]}

Lee, Il-Kwon ^{[2
]}

Kim, Nan Young ^{[2
]}

Minden, Mark D. ^{[3
]}

Jung, Chul Won ^{[4
]}

Jang, Jun-Ho ^{[4
]}

Kim, Hee Je ^{[5
]}

Moon, Joon Ho ^{[6
]}

Sohn, Sang Kyun ^{[6
]}

Won, Jong-Ho ^{[7
]}

Kim, Sung-Hyun ^{[8
]}

Kim, Namshin ^{[9
]}

Yoshida, Kenichi ^{[10
]}

Ogawa, Seishi ^{[10
]}

Kim, Dennis Dong Hwan ^{[3
]}

机构：

[1] Chonnam Natl Univ, Hwasun Hosp, Hematol Oncol, Jeollanam Do, South Korea

[2] Chonnam Natl Univ, Hwasun Hosp, Genom Res Ctr Hematopoiet Dis, Jeollanam Do, South Korea

[3] Univ Toronto, Princess Margaret Canc Ctr, Dept Med Oncol & Hematol, Toronto, ON M5S 1A1, Canada

[4] Samsung Med Ctr, Div Hematol Oncol, Seoul, South Korea

[5] Catholic Univ Korea, Dept Hematol, Seoul, South Korea

[6] Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Daegu, South Korea

[7] Soon Chun Hyang Univ Hosp, Dept Hematol Oncol, Seoul, South Korea

[8] Dong A Univ, Coll Med, Dept Hematol Oncol, Busan, South Korea

[9] Korea Res Inst Biosci & Biotechnol, Genome Inst, Epigen Res Ctr, Taejon, South Korea

[10] Kyoto Univ, Kyoto 6068501, Japan

来源：

HAEMATOLOGICA | 2015年 / 100卷 / 09期

关键词：

acute myeloid leukemia; TET2; normal karyotype; homozygous mutation; HEMATOPOIETIC STEM-CELLS; MYELODYSPLASTIC SYNDROMES; DIFFERENTIATION; LEADS; MICE;

D O I：

10.3324/haematol.2015.126227

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E351 / E353

页数：3

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