Rapid and efficient synthesis of 1-arylpiperazines under microwave irradiation

被引：20

作者：

Jaisinghani, HG ^{[1
]}

Khadilkar, BM ^{[1
]}

机构：

[1] UNIV BOMBAY,DEPT CHEM TECHNOL,BOMBAY 400019,MAHARASHTRA,INDIA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(97)01583-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Arylpiperazines, finding wide applicability in pharmaceuticals were synthesized easily under microwave irradiation from bis(2-chloroethyl)amine hydrochloride and substituted anilines without any solvent, The reaction time was just 1-3 mins. 1-Arylpiperazines were synthesized in 53 to 73% yields. Potent serotonin ligands like Trifiuoromethylphenylpiperazine (TFMPP) and 3-Chlorophenylpiperazine (mCPP) were also prepared in just 1 min, and 2 mins, respectively. (C) 1997 Elsevier Science Ltd.

引用

页码：6875 / 6876

页数：2

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