A practical route for the highly stereoselective synthesis of tetrasubstituted fluoroalkenes

被引：16

作者：

Cao, Chun-Ru ^{[1
]}

Ou, Song ^{[1
]}

Jiang, Min ^{[1
]}

Liu, Jin-Tao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 03期

基金：

中国国家自然科学基金;

关键词：

HIGH-YIELD SYNTHESIS; JULIA OLEFINATION; WEINREB AMIDES; FLUORO; PHARMACEUTICALS; EFFICIENT; SULFONES; ALKENES; ESTERS; MILD;

D O I：

10.1039/c3ob42093k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of tetrasubstituted fluoroatkene derivatives were synthesized by the reaction of alpha-fluoro-beta-carbonyl benzothiazol-2-yl sulfones with various nucleophiles in good yields with high stereoselectivities. The predominant cis configuration of fluorine and alkynyl groups was observed. A single isomer was obtained when a ketone, acetate or amide was used as the substrate in the presence of a base.

引用

页码：467 / 473

页数：7