Elucidation of the Molecular-Mechanisms and In Vivo Evaluation of the Anti-inflammatory Effect of Alginate-Derived Seleno-polymannuronate

被引：49

作者：

Bi, Decheng ^{[1
]}

Lai, Qiuxian ^{[1
]}

Cai, Nan ^{[1
]}

Li, Tong ^{[1
]}

Zhang, Yiyao ^{[1
]}

Han, Qingguo ^{[1
]}

Peng, Yanwen ^{[2
]}

Xu, Hong ^{[1
]}

Lu, Jun ^{[1
,3
,4
,5
]}

Bao, Weiyang ^{[6
]}

Liu, Qiong ^{[1
]}

Xu, Xu ^{[1
]}

机构：

[1] Shenzhen Univ, Shenzhen Key Lab Marine Bioresources & Ecol, Coll Life Sci & Oceanog, Shenzhen 518060, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Cell Gene Therapy Translat Med Res Ctr, Guangzhou 510630, Guangdong, Peoples R China

[3] Auckland Univ Technol, Sch Sci, Auckland 1142, New Zealand

[4] Auckland Univ Technol, Sch Interprofess Hlth Studies, Fac Hlth & Environm Sci, Auckland 1142, New Zealand

[5] Auckland Univ Technol, Inst Biomed Technol, Auckland 1142, New Zealand

[6] Daliarl Ocean Univ, Coll Fisheries & Life, Dalian 116023, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 09期

基金：

中国国家自然科学基金;

关键词：

seleno-polymannuronate; lipopolysaccharide; anti-inflammation; nuclear factor kappa B; mitogen-activated protein kinase; NF-KAPPA-B; NITRIC-OXIDE; ENDOPLASMIC-RETICULUM; ANTIOXIDANT ACTIVITY; OLIGOSACCHARIDE; PHAGOCYTOSIS; INFLAMMATION; POLYSACCHARIDES; RECOGNITION; DISEASE;

D O I：

10.1021/acs.jafc.7b05719

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Alginate-derived polymannuronate (PM) is a type of polysaccharide found in edible brown seaweeds. Seleno-polymannuronate (Se-PM) was prepared from PM via synthesis using sulfation- and selenation-replacement reactions. The anti-inflammatory activity of Se-PM and its corresponding molecular mechanisms were investigated. In lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells, Se-PM significantly attenuated the production of nitric oxide (NO), prostaglandin E-2 (PGE(2)), and reactive oxygen species (ROS); the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2); and the secretion of proinflammatory cytokines. Moreover, Se-PM remarkably suppressed the LPS-induced activation of the nuclear-factor (NF)-kappa B and mitogen-activated-protein-kinase (MAPK) signaling pathways in RAW264.7 cells. Furthermore, Se-PM also decreased the production of proinflammatory mediators in LPS-triggered primary murine macrophages. Additionally, Se-PM inhibited the inflammatory response in the air-pouch inflammation model. These results might contribute to the overall understanding of the potential health benefits of Se-PM for food and drug applications.

引用

页码：2083 / 2091

页数：9

共 44 条

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