Membrane rafts as a novel target in cancer therapy

被引：71

作者：

Hryniewicz-Jankowska, Anita ^{[1
]}

Augoff, Katarzyna ^{[2
]}

Biernatowska, Agnieszka ^{[1
]}

Podkalicka, Joanna ^{[1
]}

Sikorski, Aleksander F. ^{[1
]}

机构：

[1] Univ Wroclaw, Biotechnol Fac, PL-50138 Wroclaw, Poland

[2] Med Univ Wroclaw, Dept Gastrointestinal & Gen Surg, Wroclaw, Poland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2014年 / 1845卷 / 02期

关键词：

Membrane rafts; Growth factor receptor signaling; Apoptosis; Neoplasia; Cholesterol; Cancer therapy; GROWTH-FACTOR RECEPTOR; DOWNSTREAM SIGNALING MOLECULES; APOPTOTIC CELL-DEATH; KDA LAMININ RECEPTOR; RICH LIPID RAFTS; (-)-EPIGALLOCATECHIN GALLATE; MATRIX-METALLOPROTEINASE; SELECTIVE APOPTOSIS; MULTIPLE-MYELOMA; CHOLESTEROL;

D O I：

10.1016/j.bbcan.2014.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane rafts are distinct plasma membrane microdomains that are enriched in sphingolipids and cholesterol. They organize receptors and their downstream molecules and regulate a number of intracellular signaling pathways. This review presents information on the dependence of several growth factor receptor signaling pathways on membrane rafts. It also discusses the involvement of rafts in the regulation of differentiation, apoptosis and cell migration connected with invasiveness and metastasis. Examples of known synthetic and naturally occurring substances that are known to affect lateral membrane organization in tumor cell growth are discussed as potential or actual therapeutics. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：155 / 165

页数：11

共 97 条

[1] The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells [J].

Adachi, Seiji ;

Nagao, Tomokazu ;

Ingolfsson, Helgi I. ;

Maxfield, Frederick R. ;

Andersen, Olaf S. ;

Kopelovich, Levy ;

Weinstein, I. Bernard .

CANCER RESEARCH, 2007, 67 (13) :6493-6501

[2] CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells [J].

Aigner, S ;

Sthoeger, ZM ;

Fogel, M ;

Weber, E ;

Zarn, J ;

Ruppert, M ;

Zeller, Y ;

Vestweber, D ;

Stahel, R ;

Sammar, M ;

Altevogt, P .

BLOOD, 1997, 89 (09) :3385-3395

[3] Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains [J].

Annabi, B ;

Lachambre, MP ;

Bousquet-Gagnon, N ;

Pagé, M ;

Gingras, D ;

Béliveau, R .

BIOCHEMICAL JOURNAL, 2001, 353 :547-553

[4] Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling [J].

Arcaro, Alexandre ;

Aubert, Muriel ;

del Hierro, Maria E. Espinosa ;

Khanzada, Umme K. ;

Angelidou, Smaragda ;

Tetley, Teresa D. ;

Bittermann, Anne G. ;

Frame, Margaret C. ;

Seckl, Michael J. .

CELLULAR SIGNALLING, 2007, 19 (05) :1081-1092

[5] Sigma receptors and cancer: Possible involvement of ion channels [J].

Aydar, E ;

Palmer, CP ;

Djamgoz, MBA .

CANCER RESEARCH, 2004, 64 (15) :5029-5035

[6] Disruption of lipid rafts causes apoptotic cell death in HaCaT keratinocytes [J].

Bang, B ;

Gniadecki, R ;

Gajkowska, B .

EXPERIMENTAL DERMATOLOGY, 2005, 14 (04) :266-272

[7] The role of MPP1/p55 and its palmitoylation in resting state raft organization in HEL cells [J].

Biernatowska, Agnieszka ;

Podkalicka, Joanna ;

Majkowski, Michal ;

Hryniewicz-Jankowska, Anita ;

Augoff, Katarzyna ;

Kozak, Karol ;

Korzeniewski, Jan ;

Sikorski, Aleksander F. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2013, 1833 (08) :1876-1884

[8] Axis of evil: molecular mechanisms of cancer metastasis [J].

Bogenrieder, T ;

Herlyn, M .

ONCOGENE, 2003, 22 (42) :6524-6536

[9]

Bourguignon Lilly Y. W., 1998, Frontiers in Bioscience, V3, pD637

[10] PROTEIN-KINASE-B (C-AKT) IN PHOSPHATIDYLINOSITOL-3-OH INASE SIGNAL-TRANSDUCTION [J].

BURGERING, BMT ;

COFFER, PJ .

NATURE, 1995, 376 (6541) :599-602

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