Synthesis and Characterization of Chitosan Based Multilayer and pH Sensitive Co-Polymeric System for the Targeted Delivery of 5-Fluorouracil, an In Vitro Study

被引：15
|
作者：
Anirudhan, Thayyath Sreenivasan [1 ]
Binusreejayan [1 ]
Rejeena, Sylaja Raveendran [1 ]
机构：
[1] Univ Kerala, Sch Phys & Math Sci, Dept Chem, Thiruvananthapuram 695581, Kerala, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2014年 / 63卷 / 11期
关键词：
Chitosan; drug delivery; swelling controlled; in vitro release; free radical graft copolymerization; DRUG-DELIVERY; CONTROLLED-RELEASE; HYDROGELS; NANOPARTICLES; ACID; MICROSPHERES; NETWORKS;
D O I：
10.1080/00914037.2013.854225
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The principle aspiration is to develop a core shell carrier system for 5-Fluorouracil. Trisodiumcitrate crosslinked chitosan containing 5-Fluorouracil coated with cellulose acetate acts as core and copolymer of N-vinyl-2-pyrrolidone, 2-hydroxyethylmethacrylate, and itaconic acid act as shell. SEM, FTIR, and XRD studies were undertaken to characterize the samples. Swelling experiments were performed as a function of time, temperature, pH, and in simulated gastric and intestinal pH. Swelling factor was calculated for three different ions. Drug loading efficiency and in vitro release studies was done and compared. Drug delivery mechanism was found out by using Peppa's equation.
引用
收藏
页码：539 / 548
页数：10
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