AGE-RELATED MACULAR DEGENERATION

被引：0

作者：

Khandhadia, Sam ^{[1
]}

Cherry, Jocelyn ^{[1
]}

Lotery, Andrew John ^{[1
]}

机构：

[1] Southampton Gen Hosp, Dept Clin Neurosci, Southampton SO9 4XY, Hants, England

来源：

NEURODEGENERATIVE DISEASES | 2012年 / 724卷

关键词：

CHLAMYDIA-PNEUMONIAE INFECTION; RETINAL-PIGMENT EPITHELIUM; FACTOR-H POLYMORPHISM; COMPLEMENT ACTIVATION; GEOGRAPHIC ATROPHY; BRUCHS MEMBRANE; ALZHEIMERS-DISEASE; AMYLOID-BETA; ATHEROSCLEROSIS RISK; FACTOR-B;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world. Despite recent advances in treatment, AMD causes considerable morbidity. For the non-ophthalmologist, a brief background on retinal structure is provided, followed by a description of the characteristic changes seen in A MD. Subsequently the typical clinical features of A M D are discussed with an outline of present management, followed by the current theories of AMD pathogenesis. The similarities between AMD and another neurodegenerative disease are then highlighted. Finally, we review the on-going clinical trials of potential treatments for the future. Since it is clear that multiple risk factors are involved in the pathogenesis of AMD, a multi-faceted approach will most likely be required in order to prevent further patients progressing to blindness as a result of this devastating condition.

引用

页码：15 / 36

页数：22

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