A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles

被引：13

作者：

Hurst, Timothy E. ^{[1
]}

Taylor, Richard J. K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

Acridanes; Copper; Homogeneous catalysis; Nitrogen heterocycles; Cross-coupling; Dehydrogenation; One-pot reaction; HYDRIDE-TRANSFER; RING-EXPANSION; N-ARYLATION; DERIVATIVES; FUNCTIONALIZATION; TEMPERATURE; OXINDOLES; PHENOLS; ANALOGS; AMINES;

D O I：

10.1002/ejoc.201601336

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of acridanes and related compounds through a Cu-catalysed radical cross-dehydrogenative coupling of simple 2-[2-(arylamino) aryl] malonates is reported. This method can be further streamlined to a one-pot protocol involving the in situ fomation of the 2-[2-(arylamino) aryl]malonate by alpha-arylation of diethyl malonate with 2-bromodiarylamines under Pd catalysis, followed by Cu-catalysed cyclisation.

引用

页码：203 / 207

页数：5

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