A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

被引：47
|
作者：
Li, Zhen [1 ]
Fan, Jialong [1 ]
Tong, Chunyi [1 ]
Zhou, Hongyan [1 ]
Wang, Wenmiao [1 ]
Li, Bin [2 ]
Liu, Bin [1 ]
Wang, Wei [2 ]
机构：
[1] Hunan Univ, Coll Biol, Hunan Prov Key Lab Plant Funct Genom & Dev Regula, Changsha 410082, Hunan, Peoples R China
[2] Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China
来源：
NANOMEDICINE | 2019年 / 14卷 / 15期
基金：
中国国家自然科学基金;
关键词：
antitumor; carboxylated graphene quantum dots; cGQDs; folic acid; mitoxantrone; tumor-targeted therapy; OXIDE NANOSHEETS; IN-VITRO; CANCER; THERAPY; NANOPARTICLES; RELEASE; SYSTEM; BIODISTRIBUTION; MITOXANTRONE; CARRIER;
D O I：
10.2217/nnm-2018-0378
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.
引用
收藏
页码：2011 / 2025
页数：15
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