Decreased sensitivity to risk levels in ventral stratum in major depressive disorder during risky decision-making

被引：10

作者：

Gao, Feng ^{[1
,2
]}

Fan, Jie ^{[1
,2
,3
]}

Xia, Jie ^{[1
]}

Soondrum, Tamini ^{[1
]}

Liu, Wanting ^{[1
]}

Du, Hongyu ^{[1
]}

Zhu, Jiang ^{[1
]}

Tan, Changlian ^{[4
]}

Zhu, Xiongzhao ^{[1
,2
,3
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Med Psychol Ctr, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China

[2] Cent South Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China

[3] Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 2, Dept Radiol, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2021年 / 282卷

基金：

中国国家自然科学基金;

关键词：

Major depressive disorder; Risky decision-making; Balloon analog risk task; Ventral striatum; fMRI;

D O I：

10.1016/j.jad.2020.12.131

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Reduced decision-making ability in depressive people has been observed both in daily life and experimental behavioral studies. However, the neurobiology of dysfunction in decision-making among depressive people is still unclear. Methods: The study included 63 patients with major depressive disorder (MDD) and 49 healthy controls (HCs). The balloon analog risk task (BART), a risky decision-making paradigm, was used in a functional magnetic resonance imaging experiment to evaluate how brain activation was modulated by different levels of risk. Results: No significant difference in behavioral performance was found. In prespecified brain regions, the activation of the left ventral stratum (VS) in MDD patients showed reduced modulation by risk levels compared with HCs. No significant group difference was found in prespecified dorsal anterior cingulate cortex (dACC) and right dorsal lateral prefrontal cortex (DLPFC). Limitations: BART did not isolate stages of making a choice and experiencing the outcome of the choice. Conclusion: The left VS was less sensitive to risk levels in MDD patients compared with HCs, indicating inefficient reward processing in risky decision-making in MDD.

引用

页码：187 / 193

页数：7

共 37 条

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