The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome

被引：6

作者：

Chen, Mu ^{[1
]}

Fei, Yudong ^{[1
]}

Chen, Tai-Zhong ^{[1
]}

Li, Yi-Gang ^{[1
]}

Chen, Peng-Sheng ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Cardiol, Shanghai, Peoples R China

[2] Cedars Sinai Med Ctr, Dept Cardiol, Smidt Heart Inst, 8700 Beverly BLVD, Los Angeles, CA 90048 USA

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2021年 / 473卷 / 03期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Sex difference; Sex dimorphism; J wave syndrome; Brugada syndrome; Early repolarization; Ion channel; Autonomic control; CA2+-ACTIVATED K+ CHANNELS; ACTION-POTENTIAL REPOLARIZATION; SURFACE-MEMBRANE EXPRESSION; ISOLATED HEART MODEL; ATRIAL-FIBRILLATION; SK CHANNELS; NERVE-STIMULATION; VENTRICULAR-ARRHYTHMIAS; FUNCTIONAL ROLES; CHROMOSOME; 1Q21;

D O I：

10.1007/s00424-020-02500-3

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Apamin-sensitive small-conductance calcium-activated potassium (SK) current (I-KAS) plays an important role in cardiac repolarization under a variety of physiological and pathological conditions. The regulation of cardiac I-KAS relies on SK channel expression, intracellular Ca2+, and interaction between SK channel and intracellular Ca2+. I-KAS activation participates in multiple types of arrhythmias, including atrial fibrillation, ventricular tachyarrhythmias, and automaticity and conduction abnormality. Recently, sex dimorphisms in autonomic control have been noticed in I-KAS activation, resulting in sex-differentiated action potential morphology and arrhythmogenesis. This review provides an update on the Ca2+-dependent regulation of cardiac I-KAS and the role of I-KAS on arrhythmias, with a special focus on sex differences in I-KAS activation. We propose that sex dimorphism in autonomic control of I-KAS may play a role in J wave syndrome.

引用

页码：491 / 506

页数：16

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