Membrane interactions of antimicrobial peptides from Australian frogs

被引：84

作者：

Fernandez, David I. ^{[1
]}

Gehman, John D. ^{[1
]}

Separovic, Frances ^{[1
]}

机构：

[1] Univ Melbourne, Sch Chem, Inst Bio21, Melbourne, Vic 3010, Australia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2009年 / 1788卷 / 08期

基金：

澳大利亚研究理事会;

关键词：

Antimicrobial peptide; Model membrane; Peptide-lipid interaction; Pore formation; Solid-state NMR; HOST-DEFENSE PEPTIDES; TREE-FROG; SKIN GLANDS; LITORIA-GENIMACULATA; ANTIBIOTIC PEPTIDES; PART; ANTIBACTERIAL PEPTIDE; MACULATIN PEPTIDES; GRAMICIDIN-A; MECHANISM;

D O I：

10.1016/j.bbamem.2008.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The membrane interactions of four antimicrobial peptides, aurein 1.2, citropin 1.1, maculatin 1.1 and caerin 1.1, isolated from Australian tree frogs, are reviewed. All four peptides are amphipathic alpha-helices with a net positive charge and range in length from 13 to 25 residues. Despite several similar sequence characteristics, these peptides compromise the integrity of model membrane bilayers via different mechanisms; the shorter peptides exhibit a surface interaction mechanism while the longer peptides may form pores in membranes. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：1630 / 1638

页数：9

共 73 条

[1] Direct visualization of membrane leakage induced by the antibiotic peptides: Maculatin, citropin, and aurein [J].

Ambroggio, EE ;

Separovic, F ;

Bowie, JH ;

Fidelio, GD ;

Bagatolli, LA .

BIOPHYSICAL JOURNAL, 2005, 89 (03) :1874-1881

[2] Surface behaviour and peptide-lipid interactions of the antibiotic peptides, Maculatin and Citropin [J].

Ambroggio, EE ;

Separovic, F ;

Bowie, J ;

Fidelio, GD .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2004, 1664 (01) :31-37

[3] Determination of global structure from distance and orientation constraints in biological solids using solid-state NMR spectroscopy [J].

Andreas, Loren B. ;

Mehta, Anil K. ;

Mehta, Manish A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (49) :15233-15239

[4]

[Anonymous], 1998, EFFICIENT LIB PARALL

[5] Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance [J].

Apponyi, MA ;

Pukala, TL ;

Brinkworth, CS ;

Maselli, VM ;

Bowie, JH ;

Tyler, MJ ;

Booker, GW ;

Wallace, JC ;

Carver, JA ;

Separovic, F ;

Doyle, J ;

Llewellyn, LE .

PEPTIDES, 2004, 25 (06) :1035-1054

[6] Solid-state NMR study of antimicrobial peptides from Australian frogs in phospholipid membranes [J].

Balla, MS ;

Bowie, JH ;

Separovic, F .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2004, 33 (02) :109-116

[7] Structure and function of membrane-lytic peptides [J].

Bechinger, B .

CRITICAL REVIEWS IN PLANT SCIENCES, 2004, 23 (03) :271-292

[8] Membrane interactions of antimicrobial peptides from Australian tree frogs [J].

Boland, Martin P. ;

Separovic, Frances .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2006, 1758 (09) :1178-1183

[9] Negative ion electrospray mass spectra of the maculatin peptides from the tree frogs Litoria genimaculata and Litoria eucnemis [J].

Brinkworth, CS ;

Bowie, JH .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2003, 17 (19) :2215-2225

[10] THE MOLECULAR-BASIS FOR THE MODE OF ACTION OF BETA-LACTAM ANTIBIOTICS AND MECHANISMS OF RESISTANCE [J].

BYCROFT, BW ;

SHUTE, RE .

PHARMACEUTICAL RESEARCH, 1985, (01) :3-14

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