Developing an efficient route to the synthesis of nucleoside 1-alkynylphosphonates

被引：10

作者：

Meurillon, Maia ^{[1
]}

Gallier, Franck ^{[1
]}

Peyrottes, Suzanne ^{[1
]}

Perigaud, Christian ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS,UMR 5247,UM2, IBMM, Equipe Nucleosides & Effecteurs Phosphoryles,UM1, F-34095 Montpellier 05, France

来源：

TETRAHEDRON | 2009年 / 65卷 / 31期

关键词：

Nucleotide analogue; 1-Alkynylphosphonate; Sugar phosphonate; 1,1-DIBROMO-1-ALKENES; DERIVATIVES; ANALOGS;

D O I：

10.1016/j.tet.2009.05.064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of ribonucleoside 1-alkynylphosphonates have been synthesized using a palladium-catalyzed phosphonylation of terminal 1,1-dibromo-1-alkene nucleosidic derivatives and high selectivity for product distribution was observed during this step. Both nucleosidic and osidic pathways were explored and the corresponding optimization study is reported herein. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6039 / 6046

页数：8

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