Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice

被引：8

作者：

Park, Hongsun ^{[1
]}

Miyazaki, Haruko ^{[1
]}

Yamanaka, Tomoyuki ^{[1
]}

Nukina, Nobuyuki ^{[1
]}

机构：

[1] Doshisha Univ, Lab Struct Neuropathol, Grad Sch Brain Sci, 1-3 Miyakodanitatara, Kyotanabe, Kyoto 6100394, Japan

来源：

NEUROSCIENCE RESEARCH | 2019年 / 147卷

关键词：

Gene expression; Non-coding RNA; Huntington disease; Abhd11os; Neat1; ViewRNA in situ hybridization; Microarray; GENE-EXPRESSION; MOUSE MODELS; POLYGLUTAMINE; TRANSCRIPTION; PARASPECKLES; REPEAT;

D O I：

10.1016/j.neures.2018.10.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects the transcriptional profile of neurons by disrupting the activities of transcriptional machinery and alters expression of many genes. In this study, we identified dysregulated non-coding RNAs (ncRNAs) in medium spiny neurons of 4-week-old HD model mouse. Also, we observed the intracellular localizations of Abhd11os and Neat1 ncRNAs by ViewRNA in situ hybridization, which could provide more precise detection, suggesting that it is a useful method to investigate the expression changes of genes with low expression levels. (C) 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.

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收藏

页码：58 / 63

页数：6

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