Forced diuresis with matched hydration in reducing acute kidney injury during transcatheter aortic valve implantation (Reduce-AKI): study protocol for a randomized sham-controlled trial

被引：15

作者：

Arbel, Yaron ^{[1
]}

Ben-Assa, Eyal ^{[1
]}

Halkin, Amir ^{[1
]}

Keren, Gad ^{[1
]}

Schwartz, Arie Lorin ^{[1
]}

Havakuk, Ofer ^{[1
]}

Leshem-Rubinow, Eran ^{[1
]}

Konigstein, Maayan ^{[1
]}

Steinvil, Arie ^{[1
]}

Abramowitz, Yigal ^{[1
]}

Finkelstein, Ariel ^{[1
]}

Banai, Shmuel ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Med Ctr, Dept Cardiol, IL-69978 Tel Aviv, Israel

来源：

TRIALS | 2014年 / 15卷

关键词：

ACADEMIC RESEARCH CONSORTIUM; CONTRAST-INDUCED NEPHROPATHY; END-POINT DEFINITIONS; CONSENSUS REPORT; CLINICAL-TRIALS; RENAL-FUNCTION; FUROSEMIDE; REPLACEMENT; PREDICTORS; CRITERIA;

D O I：

10.1186/1745-6215-15-262

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Acute kidney injury (AKI) is observed in up to 41% of patients undergoing transcatheter aortic valve implantation (TAVI) and is associated with increased risk for mortality. The aim of the present study is to evaluate whether furosemide-induced diuresis with matched isotonic intravenous hydration using the RenalGuard system reduces AKI in patients undergoing TAVI. Methods/Design: Reduce AKI is a randomized sham-controlled study designed to examine the effect of an automated matched hydration system in the prevention of AKI in patients undergoing TAVI. Patients will be randomized in a 1: 1 fashion to the RenalGuard system (active group) versus non-matched saline infusion (sham-controlled group). Both arms receive standard overnight saline infusion and N-acetyl cysteine before the procedure. Discussion: The Reduce-AKI trial will investigate whether the use of automated forced diuresis with matched saline infusion is an effective therapeutic tool to reduce the occurrence of AKI in patients undergoing TAVI.

引用

页数：8

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