Formal [4+2] annulation of enaminones and cyanomethyl sulfur ylide: one-pot access to polysubstituted pyridin-2(1H)-ones

被引：28

作者：

Zhang, Qian ^{[1
]}

Liu, Xu ^{[1
]}

Xin, Xiaoqing ^{[1
]}

Zhang, Rui ^{[1
]}

Liang, Yongjiu ^{[1
]}

Dong, Dewen ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 97期

基金：

中国国家自然科学基金;

关键词：

DIELS-ALDER REACTIONS; ENANTIOSELECTIVE SYNTHESIS; (20S)-CAMPTOTHECIN FAMILY; EFFICIENT SYNTHESIS; CLOSING METATHESIS; SYNTHETIC METHODS; CONCISE SYNTHESIS; BRASSARDS DIENE; DELTA-LACTAMS; ACID;

D O I：

10.1039/c4cc06665k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from readily available enaminones and the cyanomethyl sulfonium bromide salt in the presence of cesium carbonate is developed, and a mechanism involving sequential nucleophilic vinylic substitution (SNV), intramolecular nucleophilic cyclization and dealkylation reactions is proposed.

引用

页码：15378 / 15380

页数：3

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