KIR2DL4 (CD158d) polymorphisms and susceptibility to multiple sclerosis

被引：5

作者：

Goris, An ^{[1
]}

Dobosi, Rita ^{[1
]}

Boonen, Steven ^{[2
,3
]}

Nagels, Guy ^{[4
]}

Dubois, Benedicte ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Sect Expt Neurol, Lab Neuroimmunol, B-3000 Louvain, Belgium

[2] Univ Leuven, Ctr Metab Bone Dis, B-3000 Louvain, Belgium

[3] Univ Leuven, Div Geriatr Med, B-3000 Louvain, Belgium

[4] Natl MS Ctr Melsbroek, B-1820 Melsbroek, Belgium

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 210卷 / 1-2期

关键词：

Multiple sclerosis; Natural killer cells; KIR2DL4; Association; Genetics; Autoimmunity; NATURAL-KILLER-CELLS; INTERLEUKIN-7; RECEPTOR; NK CELLS; ALLELES; RISK;

D O I：

10.1016/j.jneuroim.2009.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several lines of evidence implicate CD56(bright) NK cells in the pathogenesis of multiple sclerosis (MS). This proposed immunoregulatory pathway involves already established susceptibility genes such as interleukin-2 receptor alpha (IL2RA) and interleukin-7 receptor (IL7R). We therefore investigated the CD56(bright) NK cell effector molecule KIR2DL4 for its involvement in genetic susceptibility to MS in a study population of 763 cases and 967 controls. Whereas 26% of the study population has a genotype corresponding to a lack of any functional membrane-bound form of the molecule, no association of the KIR2DL4 transmembrane alleles with susceptibility to MS was observed. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：113 / 115

页数：3

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