Proton Channel Activity of Influenza A Virus Matrix Protein 2 Contributes to Autophagy Arrest

被引：43

作者：

Ren, Yizhong ^{[1
,3
]}

Li, Chufang ^{[2
]}

Feng, Liqiang ^{[3
]}

Pan, Weiqi ^{[2
]}

Li, Liang ^{[2
]}

Wang, Qian ^{[3
]}

Li, Jiashun ^{[2
]}

Li, Na ^{[2
]}

Han, Ling ^{[2
]}

Zheng, Xuehua ^{[2
]}

Niu, Xuefeng ^{[2
]}

Sun, Caijun ^{[3
]}

Chen, Ling ^{[2
,3
]}

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China

[2] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Dis, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China

[3] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 01期

关键词：

ION-CHANNEL; M2; PROTEIN; H7N9; VIRUS; CELL-DEATH; REPLICATION; DEGRADATION; INHIBITION; INFECTION; MACROAUTOPHAGY; ACTIVATION;

D O I：

10.1128/JVI.00576-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus matrix protein 2 (M2). Thus, M2 proton channel activity plays a role in blocking the fusion of autophagosomes with lysosomes, which might be a key mechanism for arresting autophagy.

引用

页码：591 / 598

页数：8

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