Polymer-supported ferrocenyl oxazolines for the catalyzed highly enantioselective phenyl transfer to aldehydes

被引：45
|
作者：
Bolm, C [1 ]
Hermanns, N [1 ]
Classen, A [1 ]
Muñiz, K [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 14期
关键词：
D O I：
10.1016/S0960-894X(02)00271-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new chiral MeO-PEG-supported ferrocenyl oxazoline was synthesized and successfully employed in the enantioselective phenyl transfer to aldehydes. The products were obtained in high yields and with excellent enantioselectivities (up to 97% ee). Furthermore, the recovery of the ferrocene was facile, and catalyst efficiency was maintained in subsequent reactions. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1795 / 1798
页数：4
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