Polymer-supported ferrocenyl oxazolines for the catalyzed highly enantioselective phenyl transfer to aldehydes

被引：45
作者：
Bolm, C [1 ]
Hermanns, N [1 ]
Classen, A [1 ]
Muñiz, K [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 14期
关键词：
D O I：
10.1016/S0960-894X(02)00271-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new chiral MeO-PEG-supported ferrocenyl oxazoline was synthesized and successfully employed in the enantioselective phenyl transfer to aldehydes. The products were obtained in high yields and with excellent enantioselectivities (up to 97% ee). Furthermore, the recovery of the ferrocene was facile, and catalyst efficiency was maintained in subsequent reactions. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：1795 / 1798
页数：4
相关论文
共 32 条
[1]   The use of soluble polymers to effect homogeneous catalyst separation and reuse [J].
Bergbreiter, DE .
CATALYSIS TODAY, 1998, 42 (04) :389-397
[2]  
Blaser H., 1999, COMPREHENSIVE ASYMME, V3, P1427
[3]  
Bolm C, 1998, EUR J ORG CHEM, V1998, P21, DOI 10.1002/(SICI)1099-0690(199801)1998:1<21::AID-EJOC21>3.0.CO
[4]  
2-0
[5]   Catalytic enantioselective aryl transfer:: asymmetric addition of diphenylzinc to aldehydes [J].
Bolm, C ;
Muñiz, K .
CHEMICAL COMMUNICATIONS, 1999, (14) :1295-1296
[6]  
Bolm C, 2001, ANGEW CHEM INT EDIT, V40, P1488, DOI 10.1002/1521-3773(20010417)40:8<1488::AID-ANIE1488>3.0.CO
[7]  
2-B
[8]   A novel ferrocenyl diselenide for the catalytic asymmetric aryl transfer to aldehydes [J].
Bolm, C ;
Kesselgruber, M ;
Grenz, A ;
Hermanns, N ;
Hildebrand, JP .
NEW JOURNAL OF CHEMISTRY, 2001, 25 (01) :13-15
[9]   Synthesis of novel 1,1′-bis(oxazolinyl)metallocenes and their application in the asymmetric phenyl transfer from organozincs to aldehydes [J].
Bolm, C ;
Hermanns, N ;
Kesselgruber, M ;
Hildebrand, JP .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2001, 624 (1-2) :157-161
[10]  
Bolm C, 2001, ANGEW CHEM INT EDIT, V40, P3285
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