Convergent one-pot synthesis of 3-substituted quinazolin-4(3H)-ones under solvent-free conditions

被引：16

作者：

Rad-Moghadam, Kurosh ^{[1
]}

Mamghani, Manoochehr ^{[1
]}

Samavi, Laleh ^{[1
]}

机构：

[1] Guilan Univ, Dept Chem, Rasht, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 15期

关键词：

formic acid; isatoic anhydride; microwave; quinazolin-4(3H)-one; solvent-free;

D O I：

10.1080/00397910600639257

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for the synthesis of 3-substituted quinazolin-4(3H)-ones using the convergent reactions of formic acid, a primary amine, and isatoic anhydride under solvent-free conditions and with brief microwave irradiation is described.

引用

页码：2245 / 2252

页数：8

共 24 条

[1]

ABDELRAHMAN MM, 1990, B PHARM SCI, V13, P137

[2] Microwave-assisted Niementowski reaction. Back to the roots [J].

Alexandre, FR ;

Berecibar, A ;

Besson, T .

TETRAHEDRON LETTERS, 2002, 43 (21) :3911-3913

[3]

BROWN A V, 1984, Freshwater Invertebrate Biology, V3, P2, DOI 10.2307/1467127

[4]

BROWN DJ, 1996, CHEM HETEROCYCLIC S1, V55

[5] Isatoic anhydride I Reactions with primary and secondary amines and with some amides [J].

Clark, RH ;

Wagner, EC .

JOURNAL OF ORGANIC CHEMISTRY, 1944, 9 (01) :55-67

[6] Green chemical multi-component one-pot synthesis of fluorinated 2,3-disubstituted quinazolin-4(3H)-ones under solvent-free conditions and their anti-fungal activity [J].

Dandia, A ;

Singh, R ;

Sarawgi, P .

JOURNAL OF FLUORINE CHEMISTRY, 2005, 126 (03) :307-312

[7]

FISNEROVA L, Patent No. 269461

[8] SYNTHESIS OF LIN-BENZOALLOPURINOL [J].

FOSTER, RH ;

LEONARD, NJ .

JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (25) :4609-4611

[9] NOVEL 4-PHENOXY-2-(1-PIPERAZINYL)QUINAZOLINES AS POTENT ANTICONVULSIVE AND ANTIHYPOXIC AGENTS [J].

HORI, M ;

IEMURA, R ;

HARA, H ;

OZAKI, A ;

SUKAMOTO, T ;

OHTAKA, H .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (03) :681-687

[10]

Jackman AL, 1997, CLIN CANCER RES, V3, P911

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