Bradykinin is involved in hyperalgesia induced by Bothrops jararaca venom

被引：19
|
作者：
Chacur, M
Picolo, G
Teixeira, CFP
Cury, Y
机构：
[1] Inst Butantan, Lab Fisiopatol, BR-05503900 Sao Paulo, Brazil
[2] Inst Butantan, Farmacol Lab, BR-05503900 Sao Paulo, Brazil
来源：
TOXICON | 2002年 / 40卷 / 07期
基金：
巴西圣保罗研究基金会;
关键词：
Bothrops jararaca venom; hyperalgesia; bradykinin;
D O I：
10.1016/S0041-0101(02)00089-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bradykinin is involved in hyperalgesia (pain hypersensitivity) induced by Bothrops jararaca venom-intraplantar injection of B. jararaca venom (5 mug/paw) in rats caused hyperalgesia, which peaked 1 h after venom injection. This phenomenon was not modified by promethazine, (H-1 receptor antagonist), methysergide (5-HT receptor antagonist), guanethidine (sympathetic function inhibitor), anti-TNF-alpha or anti-interleukin-1 antibodies or by the chelating agent CaNa(2)EDTA. Venom-induced hyperalgesia was blocked by the bradykinin B-2 receptor antagonist HOE 140. On the other hand, des-Arg(9), [Leu(8)]-bradykinin, a bradykinin B-1 receptor antagonist, did not modify the hyperalgesic response. These results suggest that bradykinin, acting on B-2 receptor, is a mediator of hyperalgesia induced by B. jararaca venom. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1047 / 1051
页数：5
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