Fourfold faster rate of genome rearrangement in nematodes than in Drosophila

被引：160

作者：

Coghlan, A ^{[1
]}

Wolfe, KH ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Dept Genet, Smurfit Inst, Dublin 2, Ireland

来源：

GENOME RESEARCH | 2002年 / 12卷 / 06期

关键词：

D O I：

10.1101/gr.172702

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio of translocations to inversions to transpositions being similar to1:1:2. We estimate that the species diverged 50-120 million years ago, and that since then there have been 4030 rearrangements between their whole genomes. Our estimate of the rearrangement rate, 0.4-1.0 chromosomal breakages/Mb per Myr, is at least four times that of Drosophila, which was previously reported to be the fastest rate among eukaryotes. The breakpoints of translocations are strongly associated with dispersed repeats and gene family members in the C elegans genome.

引用

页码：857 / 867

页数：11

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