Antihypertensive Effect of Blueberry Leaves on Spontaneously Hypertensive Rats

被引：0
作者：
Matsuura, Yasushi [1 ,2 ]
Kaneko, Mao [3 ]
Hirabaru, Hideaki [4 ]
Hidaka, Fumie [4 ]
Sakaida, Hiroshi [4 ]
Kai, Takanori [4 ]
Yukizaki, Chizuko [2 ]
Sakono, Masanobu [2 ,3 ]
机构：
[1] Miyazaki Univ, Interdisciplinary Grad Sch Agr & Engn, Miyazaki 8892192, Japan
[2] Miyazaki Prefectural Food R & D Ctr, Sadowara, Miyazaki 8800303, Japan
[3] Miyazaki Univ, Miyazaki 8892192, Japan
[4] Unkai Shuzo Co Ltd, Res Inst, Aya, Miyazaki 8801303, Japan
来源：
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI | 2013年 / 60卷 / 12期
关键词：
blueberry leaves; proanthocyanidin; lifestyle disease; anti-hypertensive; ANGIOTENSIN-CONVERTING ENZYME; VACCINIUM-ASHEI; BLOOD-PRESSURE; CRUDE DRUGS; PROANTHOCYANIDINS; INHIBITORS;
D O I：
暂无
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
We evaluated the effects of dried blueberry leaves (BL) and its hot-water extract (BLEx) on blood pressure of spontaneously hypertensive rats (SHR). A continuous 3-week administration of BL (3%) and BLEx (1.5%) reduced systolic blood pressure compared to the control group from the 2-week feeding point Additionally, we fractionated BLEx and investigated the compound responsible for the enhanced blood pressure-lowering effect. BLEx were fractionated into 5-fractions using Sephadex LH-20 and Diaion HP20SS chromatography, and assayed for angiotensin-I-converting enzyme (ACE) inhibitory activity in vitro. The fraction composed of proanthocyanidins showed the most potent inhibitory activity (IC50, 0.004 mg/mL) and reduced systolic blood pressure of SHR. These results suggest that BL and BLEx have anti-hypertensive effects and one of the active components has been identified as a proanthocyanidin.
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页码：689 / 694
页数：6
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