Wnt Signaling in Skeletal Muscle Development and Regeneration

被引：124

作者：

Girardi, Francesco ^{[1
]}

Le Grand, Fabien ^{[1
]}

机构：

[1] UPMC Univ Paris 06, Sorbonne Univ, Ctr Res Myol, INSERM,UMRS974, Paris, France

来源：

WNT SIGNALING IN HEALTH AND DISEASE | 2018年 / 153卷

关键词：

WNT/BETA-CATENIN PATHWAY; BETA-CATENIN; STEM-CELLS; SELF-RENEWAL; MYOGENIC DIFFERENTIATION; SATELLITE CELLS; ACTIVATION; EXPRESSION; MYOD; PROLIFERATION;

D O I：

10.1016/bs.pmbts.2017.11.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt is a family of signaling molecules involved in embryogenesis, adult tissue repair, and cancer. They activate canonical and noncanonical Wnt signaling cascades in target cells. Several studies, within the last decades, showed that several Wnt ligands are involved in myogenesis and both canonical and noncanonical Wnt pathways regulate muscle formation and the maintenance of adult tissue homeostasis. In this review, we provide a comprehensive overview of the roles of Wnt signaling during muscle development and an updated description of Wnt functions during muscle repair. Lastly, we discuss the crosstalk between Wnt and TGF beta signaling pathways in skeletal muscle.

引用

页码：157 / 179

页数：23

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