Wnt Signaling in Skeletal Muscle Development and Regeneration

被引:121
作者
Girardi, Francesco [1 ]
Le Grand, Fabien [1 ]
机构
[1] UPMC Univ Paris 06, Sorbonne Univ, Ctr Res Myol, INSERM,UMRS974, Paris, France
来源
WNT SIGNALING IN HEALTH AND DISEASE | 2018年 / 153卷
关键词
WNT/BETA-CATENIN PATHWAY; BETA-CATENIN; STEM-CELLS; SELF-RENEWAL; MYOGENIC DIFFERENTIATION; SATELLITE CELLS; ACTIVATION; EXPRESSION; MYOD; PROLIFERATION;
D O I
10.1016/bs.pmbts.2017.11.026
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Wnt is a family of signaling molecules involved in embryogenesis, adult tissue repair, and cancer. They activate canonical and noncanonical Wnt signaling cascades in target cells. Several studies, within the last decades, showed that several Wnt ligands are involved in myogenesis and both canonical and noncanonical Wnt pathways regulate muscle formation and the maintenance of adult tissue homeostasis. In this review, we provide a comprehensive overview of the roles of Wnt signaling during muscle development and an updated description of Wnt functions during muscle repair. Lastly, we discuss the crosstalk between Wnt and TGF beta signaling pathways in skeletal muscle.
引用
收藏
页码:157 / 179
页数:23
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