Structure-function analysis of the anti-proliferative effect of the human guanylate binding protein-1 (GBP-1) in endothelial cells

被引：0

作者：

Töpolt, K ^{[1
]}

Guenzi, E ^{[1
]}

Lubeseder-Martellato, C ^{[1
]}

Jörg, A ^{[1
]}

Naschberger, E ^{[1
]}

Stürzl, M ^{[1
]}

机构：

[1] GSF, Natl Res Ctr Environm & Hlth, Inst Mol Virol, Dept Virus Induced Vasculopathy, Neuherberg, Germany

来源：

22ND MEETING OF THE EUROPEAN SOCIETY FOR MICROCIRCULATION: MICROCIRCULATION AND VASCULAR BIOLOGY | 2002年

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammatory cytokines (IC) are potent inhibitors of endothelial cell proliferation. As a specific mediator of the anti-proliferative effect of IC on endothelial cells (EC) we identified the large GTPase human guanylate binding protein-1 (GBP-1). Ectopic expression of GBP-1 in EC inhibited angiogenic growth factor (AGF)-induced proliferation, whereas inhibition of IC-induced GBP-1 expression by GBP-1 antisense RNA abrogated the anti-proliferative effect of IC. GBP-1 selectively inhibited the proliferation of endothelial cells in the absence of apoptosis and without affecting adhesiveness for monocytes, morphogenesis or ERK 1/2 activation. Structure-function-analysis conveyed that the anti-proliferative effect is mediated specifically by the helical domain of GBP-1 and independent of isoprenylation or GTP-hydrolysis.

引用

页码：215 / 219

页数：5

共 50 条

[11] Structure-function analysis of Vg1RNA binding protein
Rand, K
Oberman, F
Yisraeli, JK
DEVELOPMENTAL BIOLOGY, 2003, 259 (02) : 480 - 480
[12] PINK1: an anti-apoptotic and anti-proliferative protein in human breast cancer cells
Jimenez-Sainz, J.
Berthier, A.
Pulido, R.
FEBS JOURNAL, 2012, 279 : 320 - 320
[13] Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii
Qin, Aiping
Lai, De-Hua
Liu, Qifa
Huang, Weijun
Wu, Ya-Ping
Chen, Xiaoyong
Yan, Sunxing
Xia, Huimin
Hide, Geoff
Lun, Zhao-Rong
Ayala, Francisco J.
Xiang, Andy Peng
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (06) : 1365 - 1370
[14] Guanylate binding protein-1 inhibits spreading and migration of endothelial cells through induction of integrin α4 expression
Weinlaender, Kristina
Naschberger, Elisabeth
Lehmann, Michael H.
Tripal, Philipp
Paster, Wolfgang
Stockinger, Hannes
Hohenadl, Christine
Stuerzl, Michael
FASEB JOURNAL, 2008, 22 (12): : 4168 - 4178
[15] Airway smooth muscle cells are insensitive to the anti-proliferative effects of corticosteroids: The novel role of insulin growth factor binding Protein-1 in asthma
Bui, Hong
Amrani, Yassine
Deeney, Brian
Panettieri, Reynold A.
Tliba, Omar
IMMUNOBIOLOGY, 2019, 224 (04) : 490 - 496
[16] Airway Smooth Muscle Cells Are Insensitive To The Anti-Proliferative Effects Of Glucocorticoids: The Novel Role Of Insulin Growth Factor Binding Protein-1 In Asthma
Bui, H.
Amrani, Y.
Panettieri, R. A., Jr.
Tliba, O.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
[17] Insight into Temperature Dependence of GTPase Activity in Human Guanylate Binding Protein-1
Rani, Anjana
Pandita, Esha
Rahman, Safikur
Deep, Shashank
Sau, Apurba Kumar
PLOS ONE, 2012, 7 (07):
[18] The potential anti-proliferative effect of β-sitosterol on human mast cell line-1 cells
Han, Na-Ra
Kim, Hyung-Min
Jeong, Hyun-Ja
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2015, 93 (11) : 979 - 983
[19] Structure-function analysis of human protein Ero1-Lα
Chu, Yanyan
Yang, Charles
Chen, Xianjun
Zheng, Wenyun
Yang, Yi
Tang, Yun
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 389 (04) : 645 - 650
[20] The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression
Guenzi, E
Töpolt, K
Lubeseder-Martellato, C
Jörg, A
Naschberger, E
Benelli, R
Albini, A
Stürzl, M
EMBO JOURNAL, 2003, 22 (15): : 3772 - 3782

← 1 2 3 4 5 →