Identification of chick frizzled-10 expressed in the developing limb and the central nervous system

被引：21

作者：

Kawakami, Y

Wada, N

Nishimatsu, S

Komaguchi, C

Noji, S

Nohno, T ^{[1
]}

机构：

[1] Kawasaki Med Sch, Dept Mol Biol, Kurashiki, Okayama 7010192, Japan

[2] Univ Tokushima, Fac Engn, Dept Biol Sci & Technol, Tokushima 7708506, Japan

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 91卷 / 1-2期

关键词：

frizzled-10; Wnt receptor; Wnt; sonic hedgehog; limb development; epithelial-mesenchymal interaction;

D O I：

10.1016/S0925-4773(99)00301-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have identified chick frizzled (Fz)-10, encoding a Wnt receptor, and examined the expression pattern during embryogenesis. Fz-10 is expressed in the region posterior to the Hensen's node at stage 6. Fz-10 expression is detected in the dorsal domain of the neural tube and the central nervous system of the developing embryo. In the developing limb, Fz-10 expression starts at stage 18 in the posterior-dorsal region of the distal mesenchyme, and gradually expands to the anterior-distal region. Fz-10 is also expressed in the feather bud and branchial arch. Implantation of Sonic hedgehog (Shh)-expressing cells into the anterior margin of the limb bud resulted in the induction of Fz-10 expression in anterior-dorsal mesenchyme. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：375 / 378

页数：4