How Generalizable Are Randomized Controlled Trials (RCTs) in Staphylococcus aureus Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies

被引：13

作者：

Bai, Anthony D. ^{[1
,2
]}

Lo, Carson K. L. ^{[3
]}

Komorowski, Adam S. ^{[2
,4
]}

Suresh, Mallika ^{[5
]}

Guo, Kevin ^{[6
]}

Garg, Akhil ^{[7
]}

Tandon, Pranav ^{[8
]}

Senecal, Julien ^{[9
]}

Del Corpo, Olivier ^{[10
]}

Stefanova, Isabella ^{[5
]}

Fogarty, Clare ^{[11
]}

Butler-Laporte, Guillaume ^{[12
]}

McDonald, Emily G. ^{[13
]}

Cheng, Matthew P. ^{[14
]}

Morris, Andrew M. ^{[15
,16
]}

Loeb, Mark ^{[2
,3
,4
]}

Lee, Todd C. ^{[13
]}

机构：

[1] Queens Univ, Dept Med, Div Infect Dis, Etherington Hall Room 3010 94 Stuart St, Kingston, ON K7L 3N6, Canada

[2] McMaster Univ, Fac Hlth Sci, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[3] McMaster Univ, Dept Med, Div Infect Dis, Hamilton, ON, Canada

[4] McMaster Univ, Dept Pathol & Mol Med, Div Med Microbiol, Hamilton, ON, Canada

[5] McMaster Univ, Michael G DeGroote Sch Med, Hamilton, ON, Canada

[6] McMaster Univ, Fac Hlth Sci, Hamilton, ON, Canada

[7] Queens Univ, Dept Med, Kingston, ON, Canada

[8] Univ Toronto, Temerty Fac Med, Toronto, ON, Canada

[9] McGill Univ, Fac Med & Hlth Sci, Montreal, PQ, Canada

[10] McGill Univ, Dept Med, Div Expt Med, Div Infect Dis, Montreal, PQ, Canada

[11] McGill Univ, Hlth Ctr, Montreal, PQ, Canada

[12] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada

[13] McGill Univ, Dept Med, Clin Practice Assessment Unit, Montreal, PQ, Canada

[14] McGill Univ, Div Infect Dis & Med Microbiol, Hlth Ctr, Montreal, PQ, Canada

[15] Univ Hlth Network, Sinai Hlth, Dept Med, Div Infect Dis, Toronto, ON, Canada

[16] Univ Toronto, Toronto, ON, Canada

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 75卷 / 08期

关键词：

Staphylococcus aureus; bacteremia; mortality; trials; BETA-LACTAM; MULTICENTER; DAPTOMYCIN; VANCOMYCIN; THERAPY;

D O I：

10.1093/cid/ciac177

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths in RCTs contribute to this mortality gap. Clinicians should acknowledge the possibility of a lower treatment effect when applying RCT results to bedside care.

引用

页码：1449 / 1452

页数：4

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