An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia

被引：7

作者：

Dell'Acqua, Raffaele ^{[1
]}

Fabrizio, Claudia ^{[1
]}

Di Gennaro, Francesco ^{[1
]}

Lo Caputo, Sergio ^{[1
]}

Saracino, Annalisa ^{[1
]}

Menegon, Michela ^{[2
]}

L'Episcopia, Mariangela ^{[2
]}

Severini, Carlo ^{[2
]}

Monno, Laura ^{[1
]}

Castelli, Francesco ^{[3
]}

Angarano, Gioacchino ^{[1
]}

机构：

[1] Univ Bari Aldo Moro, Clin Infect Dis, Piazza G Cesare 11, I-70124 Bari, Italy

[2] Ist Super Sanita, Dept Infect Dis, Rome, Italy

[3] Azienda Osped Spedali Civili Brescia, Univ Dept Infect & Trop Dis, Brescia, Italy

来源：

MALARIA JOURNAL | 2017年 / 16卷

关键词：

Malaria; Vivax; Falciparum; Drug resistance; Multiple; Antimalarials; Genes; MDR; Travel medicine; Cambodia; ARTEMISININ RESISTANCE; MALARIA; MUTATIONS; TRAVELER; FAILURE;

D O I：

10.1186/s12936-017-1795-y

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Imported cases of multidrug resistant Plasmodium falciparum and treatment failure with artemisinin-based regimens, although rare, have been described also in Western countries and their management is often challenging. This is also due to an inadequate knowledge and implementation of health prevention measures. Case report: A complex case of imported malaria caused by Plasmodium vivax/P. falciparum isolates in a patient who was not taking chemoprophylaxis while he was travelling in Cambodia is reported in this article. After failures of artemisinin-based and both oral and intravenous quinine-based regimens, a multidrug resistant P. falciparum was detected. The patient was successfully treated with atovaquone-proguanil. Conclusions: This experience highlights the importance of a careful management that should be based not only on the most up-to-date guidelines, but also on the awareness of a rapidly evolving scenario.

引用

页数：4

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