A brief history of Drosophila's contributions to genome research

被引：158

作者：

Rubin, GM ^{[1
]}

Lewis, EB

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

SCIENCE | 2000年 / 287卷 / 5461期

关键词：

D O I：

10.1126/science.287.5461.2216

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The sequence of the Drosophila melanogaster genome presented in this issue of Science is the latest milestone in nine decades of research on this organism. Genetic and physical mapping, whole-genome mutational screens, and functional alteration of the genome by gene transfer were pioneered in metazoans with the use of this small fruit fly. Here we Look at some of the instances in which work on Drosophila has Led to major conceptual or technical breakthroughs in our understanding of animal genomes.

引用

页码：2216 / 2218

页数：3

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