Four New Lignans from Kadsura Interior and Their Bioactivity

被引：6

作者：

Liu, Jiu-Shi ^{[1
,2
]}

Zhang, Jin ^{[1
,2
,3
]}

Qi, Yao-Dong ^{[1
,2
]}

Jia, Xiao-Guang ^{[3
]}

Zhang, Ben-Gang ^{[1
,2
]}

Liu, Hai-Tao ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] Xinjiang Med Univ, Inst Tradit Chinese Med, Urumqi 830011, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Kadsura interior; lignan; kadsutherin E-H; anti-platelet aggregation; HETEROCLITA; ACTIVATION; COCCINEA; STEMS;

D O I：

10.3390/molecules23061279

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A phytochemical investigation of the stems of Kadsura interior has led to an isolation of four new lignans, named kadsutherin E-H (1-4), together with two known lignans (5-6). The structures of the four new compounds were established on the basis of comprehensive spectroscopic analyses. Compounds 1-6 exhibited inhibition against adenosine diphosphate (ADP) induced platelet aggregation. Among the isolated compounds, kadsutherin F (2) showed the strongest anti-platelet aggregation activity with an inhibition of 49.47%.

引用

页数：9

共 18 条

[1] DIBENZOCYCLO-OCTADIENE LIGNANS FROM KADSURA-HETEROCLITA [J].

CHEN, DF ;

XU, GJ ;

YANG, XW ;

HATTORI, M ;

TEZUKA, Y ;

KIKUCHI, T ;

NAMBA, T .

PHYTOCHEMISTRY, 1992, 31 (02) :629-632

[2] Anti-AIDS agents .26. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues [J].

Chen, DF ;

Zhang, SX ;

Xie, L ;

Xie, JX ;

Chen, K ;

Kashiwada, Y ;

Zhou, BN ;

Wang, P ;

Cosentino, LM ;

Lee, KH .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (08) :1715-1723

[3] Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation [J].

Chen, DF ;

Zhang, SX ;

Kozuka, M ;

Sun, QZ ;

Feng, J ;

Wang, Q ;

Mukainaka, T ;

Nobukuni, Y ;

Tokuda, H ;

Nishino, H ;

Wang, HK ;

Morris-Natschke, SL ;

Lee, KH .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (09) :1242-1245

[4] Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior [J].

Chen, DF ;

Zhang, SX ;

Chen, K ;

Zhou, BN ;

Wang, P ;

Cosentino, LM ;

Lee, KH .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (11) :1066-1068

[5] New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria [J].

Chen, Jih-Jung ;

Tsai, Tung-Han ;

Liao, Hsiang-Ruei ;

Chen, Li-Chai ;

Kuo, Yueh-Hsiung ;

Sung, Ping-Jyun ;

Chen, Chun-Lin ;

Wei, Chun-Sheng .

MOLECULES, 2016, 21 (10)

[6] Heteroclitins R-S: new dibenzocylooctadiene lignans from Kadsura heteroclita [J].

Chen Min ;

Luo You-Ping ;

Zou Yan-Lin ;

Lang Ling-Hu ;

Chen Dao-Feng .

CHINESE JOURNAL OF NATURAL MEDICINES, 2014, 12 (09) :689-692

[7]

DING ZH, 1990, ACTA CHIM SINICA, V48, P1075

[8]

Fuly AL, 1997, THROMB HAEMOSTASIS, V78, P1372

[9]

Jiang Shi-li, 2005, Fudan Xuebao (Yixuekexueban), V32, P467

[10]

Jin X. L., 2000, Chin. Pharm. Bull., V1, P26

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