Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats

被引:61
作者
Zhou, Yu [1 ]
Fang, San-hua [1 ]
Ye, Yi-lu [1 ]
Chu, Li-sheng [1 ]
Zhang, Wei-ping [1 ]
Wang, Meng-ling [1 ]
Wei, Er-qing [1 ]
机构
[1] Zhejiang Univ, Sch Med, Dept Pharmacol, Hangzhou 310031, Peoples R China
关键词
caffeic acid; focal cerebral ischemia; neuron; astrocyte; 5-lipoxygenase; leukotriene;
D O I
10.1111/j.1745-7254.2006.00406.x
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Aim: To investigate the effects of caffeic acid on early and delayed injuries after focal cerebral ischemia in rats, and the possible relation to 5-lipoxygenase inhibition. Methods: Transient focal cerebral ischemia was induced by middle cerebral artery occlusion in Sprague-Dawley rats. Caffeic acid (10 and 50 mg/kg) was ip injected for 5 d after ischemia. The brain injuries were observed, and the levels of cysteinyl leukotrienes and leukotriene B, in the brain tissue were measured. Results: Caffeic acid (50 mg/kg) ameliorated neurological dysfunction and neuron loss, and decreased infarct volume 24 h after ischemia; it attenuated brain atrophy, infarct volume, and particularly astrocyte proliferation 14 d after ischemia. In addition, it reduced the production of leukotrienes (5-lipoxygenase metabolites) in the ischemic hemispheres 3 h and 7 d after ischemia. Conclusion: Caffeic acid has protective effect on both early and delayed injuries after focal cerebral ischemia in rats; and this effect may partly relate to 5-lipoxygenase inhibition.
引用
收藏
页码:1103 / 1110
页数:8
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