Catecholaminergic Polymorphic Ventricular Tachycardia

被引：17

作者：

Abbas, Mohamed ^{[1
]}

Miles, Chris ^{[2
,3
]}

Behr, Elijah ^{[2
,3
]}

机构：

[1] Royal Stoke Univ Hosp, Dept Cardiol, Stoke On Trent, Staffs, England

[2] St Georges Univ London, Mol & Clin Sci Inst, Cardiovasc Clin Acad Grp, London, England

[3] St Georges Univ Hosp NHS Fdn Trust, London, England

来源：

ARRHYTHMIA & ELECTROPHYSIOLOGY REVIEW | 2022年 / 11卷

关键词：

ss-blockers; catecholaminergic polymorphic ventricular tachycardia; flecainide; left cardiac sympathetic denervation; ryanodine receptor mutation; sudden cardiac death; SUDDEN UNEXPLAINED DEATH; LONG-QT SYNDROME; FOLLOW-UP; THERAPEUTIC STRATEGIES; AMERICAN-COLLEGE; RYR2; MUTATIONS; BETA-BLOCKERS; CARDIAC DEATH; EXERCISE TEST; TASK-FORCE;

D O I：

10.15420/aer.2022.09

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterised by adenergically mediated bidirectional and/or polymorphic ventricular tachycardia. CPVT is a significant cause of autopsy-negative sudden death in children and adolescents, although it can also affect adults. It is often caused by pathogenic variants in the cardiac ryanodine receptor gene as well as other rarer genes. Early identification and risk stratification is of major importance. ss-blockers are the cornerstone of therapy. Sodium channel blockers, specifically flecainide, have an additive role. Left cardiac sympathetic denervation is playing an increasing role in suppression of arrhythmia and symptoms. Concerns have been raised, however, about the efficacy of implantable cardioverter defibrillator therapy and the risk of catecholamine driven proarrhythmic storms. In this review, we summarise the clinical characteristics, genetics, and diagnostic and therapeutic strategies for CPVT and describe recent advances and challenges.

引用

页数：7

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