Pulse radiolysis studies of etoposide and 4′-demethylepipodophyllotoxin in aqueous solution

被引：1
|
作者：
Lu, CY
Wang, WF
Lin, WZ
Xu, QG
Pan, JX
Han, ZH
Yao, SD
Lin, NY
机构：
[1] Acad Sinica, Shanghai Inst Nucl Res, Lab Radiat Chem, Shanghai 201800, Peoples R China
[2] Lianyungang Pharmaceut Factory, Jiangsu 222002, Peoples R China
来源：
RADIATION PHYSICS AND CHEMISTRY | 2000年 / 57卷 / 02期
基金：
中国国家自然科学基金;
关键词：
etoposide (VP 16); DMEP; redox reactions; pulse radiolysis;
D O I：
10.1016/S0969-806X(99)00321-7
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The reactions of etoposide (VP 16, 4'-demethyl-epipodophyllotoxin ethylidene-beta-D-glucoside) and 4'-demethylepipodophyllotoxin (DMEP) with the primary radiolytic products of water, such as e(aq)(-), H-. and (OH)-O-./O.- radicals, and the secondary radical (SO4.-) in aqueous solution were studied by use of the techniques of pulse radiolysis, respectively. The absorption spectra of reaction products with e(aq)(-), H-. and (OH)-O-./O.- and SO4.- radicals were observed, and the rate constants of them were determined by following the build-up kinetics of produced or the decay of hydrated electron observed at 600 nm, respectively. (C) 2000 Elsevier Science. All rights reserved.
引用
收藏
页码：151 / 156
页数：6
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