Recent advances in 17beta-hydroxysteroid dehydrogenases

被引：51

作者：

Prehn, Cornelia ^{[1
]}

Moeller, Gabriele ^{[1
]}

Adamski, Jerzy ^{[1
,2
]}

机构：

[1] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Expt Genet, Genome Anal Ctr, D-85764 Neuherberg, Germany

[2] Tech Univ Munich, Lehrstuhl Expt Genet, D-8050 Freising Weihenstephan, Germany

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2009年 / 114卷 / 1-2期

关键词：

Steroid metabolism; Steroid-related diseases; Phylogenetics; Short-chain dehydrogenase/reductase; HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2; BIFUNCTIONAL PROTEIN-DEFICIENCY; PEROXISOMAL BETA-OXIDATION; STEROID-HORMONE METABOLISM; COENZYME-A DEHYDROGENASE; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; MOLECULAR CHARACTERIZATION; HYDROXYSTEROID DEHYDROGENASES; MULTIFUNCTIONAL PROTEIN-2; FUNCTIONAL-ANALYSIS;

D O I：

10.1016/j.jsbmb.2008.12.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The metabolism of steroids at position 17 is catalysed by a growing number of 17beta-hydroxysteroid dehydrogenases (17 beta-HSDs). Several human diseases like breast or prostate cancer, endometriosis, metabolic syndrome and mental diseases were associated with dysfunctions of 17 beta-HSDs, which consequently became drug targets. This review will focus on identities of 17 beta-HSDs and recent advances in analyses of their physiological roles in steroid and lipid metabolism. It will also address the potential of metabolomics in drug development. (C) 2009 Elsevier Ltd. All rights reserved.

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页码：72 / 77

页数：6

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