Comparison between 8-and 32-channel phased-array receive coils for in vivo hyperpolarized C-13 imaging of the human brain

被引:25
作者
Autry, Adam W. [1 ]
Gordon, Jeremy W. [1 ]
Carvajal, Lucas [1 ]
Mareyam, Azma [2 ]
Chen, Hsin-Yu [1 ]
Park, Ilwoo [3 ]
Mammoli, Daniele [1 ]
Vareth, Maryam [1 ,4 ]
Chang, Susan M. [5 ]
Wald, Lawrence L. [2 ,6 ,7 ]
Xu, Duan [1 ]
Vigneron, Daniel B. [1 ]
Nelson, Sarah J. [1 ,8 ]
Li, Yan [1 ]
机构
[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, 185 Berry St,Ste 350, San Francisco, CA 94107 USA
[2] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, Charlestown, MA USA
[3] Chonnam Natl Univ, Med Sch & Hosp, Dept Radiol, Gwangju, South Korea
[4] Univ Calif Berkeley, BIDS, Berkeley, CA 94720 USA
[5] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA
[6] Harvard Med Sch, Boston, MA 02115 USA
[7] MIT, Harvard Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA
[8] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA
关键词
32-channel; brain; carbon-13; echo-planar imaging; hyperpolarized; phased-array; MRI;
D O I
10.1002/mrm.27743
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PurposeTo compare the performance of an 8-channel surface coil/clamshell transmitter and 32-channel head array coil/birdcage transmitter for hyperpolarized C-13 brain metabolic imaging. MethodsTo determine the field homogeneity of the radiofrequency transmitters, B-1+ mapping was performed on an ethylene glycol head phantom and evaluated by means of the double angle method. Using a 3D echo-planar imaging sequence, coil sensitivity and noise-only phantom data were acquired with the 8- and 32-channel receiver arrays, and compared against data from the birdcage in transceiver mode. Multislice frequency-specific C-13 dynamic echo-planar imaging was performed on a patient with a brain tumor for each hardware configuration following injection of hyperpolarized [1-C-13]pyruvate. Signal-to-noise ratio (SNR) was evaluated from pre-whitened phantom and temporally summed patient data after coil combination based on optimal weights. ResultsThe birdcage transmitter produced more uniform B-1+ compared with the clamshell: 0.07 versus 0.12 (fractional error). Phantom experiments conducted with matched lateral housing separation demonstrated 8- versus 32-channel mean transceiver-normalized SNR performance: 0.91 versus 0.97 at the head center; 6.67 versus 2.08 on the sides; 0.66 versus 2.73 at the anterior; and 0.67 versus 3.17 on the posterior aspect. While the 8-channel receiver array showed SNR benefits along lateral aspects, the 32-channel array exhibited greater coverage and a more uniform coil-combined profile. Temporally summed, parameter-normalized patient data showed SNRmean,slice ratios (8-channel/32-channel) ranging 0.5-2.00 from apical to central brain. White matter lactate-to-pyruvate ratios were conserved across hardware: 0.45 0.12 (8-channel) versus 0.43 +/- 0.14 (32-channel). ConclusionThe 8- and 32-channel hardware configurations each have advantages in particular brain anatomy.
引用
收藏
页码:833 / 841
页数:9
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