Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite

被引：49

作者：

Gugliucci, Alejandro ^{[1
]}

Bastos, Deborah H. Markowicz ^{[2
]}

机构：

[1] Touro Univ California, Glycat Oxidat & Dis Lab, Vallejo, CA 94592 USA

[2] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-05508 Sao Paulo, Brazil

来源：

FITOTERAPIA | 2009年 / 80卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Chlorogenic acid; Polyphenols; Ilex paraguariensis; Myeloperoxidase; Chlorination; Chlorotyrosine; MYELOPEROXIDASE; OXIDATION; ATHEROSCLEROSIS; ENZYME; MODEL; PON1; DYAD;

D O I：

10.1016/j.fitote.2009.01.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 mu M) and chlorogenic acid (2-10 mu M) compatible with those found in humans. When human HDL was incubated in the presence of HOCl/OCl-, a concentration dependent loss of activity was apparent. Of interest, 5 caffeoylquinic acid at 5 mu mol/L affords more than 60% protection of the activity reaching 100% at 25 mu mol/L. This compound and the plant sources that are rich in them may be protectors of paraoxonase 1 activity. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：138 / 142

页数：5

共 22 条

[1] HDL-associated paraoxonase 1 (PON1) and dietary antioxidants attenuate upoprotein oxidation, macrophage foam cells formation and atherosclerosis development [J].