Sleep deprivation-induced reduction in cortical functional response to serial subtraction

被引：208
作者：
Drummond, SPA
Brown, GG
Stricker, JL
Buxton, RB
Wong, EC
Gillin, JC
机构：
[1] Univ Calif San Diego, Dept Psychiat, VAMC, La Jolla, CA 92161 USA
[2] San Diego State Univ Univ Calif San Diego Joint D, San Diego, CA 92182 USA
[3] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA
来源：
NEUROREPORT | 1999年 / 10卷 / 18期
关键词：
fMRI; mathematics; parietal lobe; prefrontal cortex; sleep deprivation;
D O I：
10.1097/00001756-199912160-00004
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THIRTEEN normal volunteers were studied with fMRI during arithmetic performance after a normal night of sleep and following sleep deprivation (SD). Aims included determining whether the prefrontal cortex (PFC) and the parietal lobe arithmetic areas are vulnerable to the effects of SD. After a normal night of sleep, activation localized to the bilateral PFC, parietal lobes and premotor areas. Following SD, activity in these regions decreased markedly, especially in the PFC. Performance also dropped. Data from the serial subtraction task are consistent with Home's PFC vulnerability hypothesis but, based on this and other studies, we suggest the localized, functional effects of SD in the brain may vary, in part, with the specific cognitive task. (C) 1999 Lippincott Williams & Wilkins.
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收藏
页码：3745 / 3748
页数：4
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