Direct Catalytic Hydrogenation of Simple Amides: A Highly Efficient Approach from Amides to Amines and Alcohols

被引：51

作者：

Shi, Liyang ^{[1
]}

Tan, Xuefeng ^{[1
]}

Long, Jiao ^{[1
]}

Xiong, Xiong ^{[1
]}

Yang, Song ^{[1
]}

Xue, Peng ^{[1
]}

Lv, Hui ^{[1
,2
]}

Zhang, Xumu ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

[2] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 03期

基金：

中国国家自然科学基金;

关键词：

alcohols; amides; amines; chemoselectivity; hydrogenation; SELECTIVE HYDROGENATION; ASYMMETRIC HYDROGENATION; BIFUNCTIONAL ADDITION; MECHANISM; IMIDES; COMPLEXES; ESTERS;

D O I：

10.1002/chem.201604904

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly chemoselective and reactive direct catalytic reduction of various amides to amines and alcohols was developed by using a tetradentate ruthenium complex. The catalytic system showed excellent activity (turnover numbers up to 19600) and great functional group tolerance under mild reaction conditions, compared to several bidentate and tridentate ruthenium-catalyzed systems.

引用

页码：546 / 548

页数：3

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