Conditional Gene-Targeting in Mice: Problems and Solutions

被引:53
作者
Becher, Burkhard [1 ]
Waisman, Ari [2 ]
Lu, Li-Fan [3 ,4 ]
机构
[1] Univ Zurich, Inst Expt Immunol, Zurich, Switzerland
[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, Obere Zahlbacher Str 67, D-55131 Mainz, Germany
[3] Univ Calif San Diego, Div Biol Sci, Ctr Microbiome Innovat, San Diego, CA 92093 USA
[4] Univ Calif San Diego, Moores Canc Ctr, San Diego, CA 92093 USA
关键词
D O I
10.1016/j.immuni.2018.05.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:835 / 836
页数:2
相关论文
共 10 条
[1]   The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity [J].
Croxford, Andrew L. ;
Lanzinger, Margit ;
Hartmann, Felix J. ;
Schreiner, Bettina ;
Mair, Florian ;
Pelczar, Pawel ;
Clausen, Bjoern E. ;
Jung, Steffen ;
Greter, Melanie ;
Becher, Burkhard .
IMMUNITY, 2015, 43 (03) :502-514
[2]   Targeting cre recombinase to specific neuron Populations with bacterial artificial chromosome constructs [J].
Gong, Shiaoching ;
Doughty, Martin ;
Harbaugh, Carroll R. ;
Cummins, Alexander ;
Hatten, Mary E. ;
Heintz, Nathaniel ;
Gerfen, Charles R. .
JOURNAL OF NEUROSCIENCE, 2007, 27 (37) :9817-9823
[3]   DELETION OF A DNA-POLYMERASE-BETA GENE SEGMENT IN T-CELLS USING CELL-TYPE-SPECIFIC GENE TARGETING [J].
GU, H ;
MARTH, JD ;
ORBAN, PC ;
MOSSMANN, H ;
RAJEWSKY, K .
SCIENCE, 1994, 265 (5168) :103-106
[4]   Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource [J].
Heffner, Caleb S. ;
Pratt, C. Herbert ;
Babiuk, Randal P. ;
Sharma, Yashoda ;
Rockwood, Stephen F. ;
Donahue, Leah R. ;
Eppig, Janan T. ;
Murray, Stephen A. .
NATURE COMMUNICATIONS, 2012, 3
[5]   Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination [J].
Klein, Ulf ;
Casola, Stefano ;
Cattoretti, Giorgio ;
Shen, Qiong ;
Lia, Marie ;
Mo, Tongwei ;
Ludwig, Thomas ;
Rajewsky, Klaus ;
Dalla-Favera, Riccardo .
NATURE IMMUNOLOGY, 2006, 7 (07) :773-782
[6]   A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival [J].
Lee, PP ;
Fitzpatrick, DR ;
Beard, C ;
Jessup, HK ;
Lehar, S ;
Makar, KW ;
Pérez-Melgosa, M ;
Sweetser, MT ;
Schlissel, MS ;
Nguyen, S ;
Cherry, SR ;
Tsai, JH ;
Tucker, SM ;
Weaver, WM ;
Kelso, A ;
Jaenisch, R ;
Wilson, CB .
IMMUNITY, 2001, 15 (05) :763-774
[7]   B lymphocyte-specific, Cre-mediated mutagenesis in mice [J].
Rickert, RC ;
Roes, J ;
Rajewsky, K .
NUCLEIC ACIDS RESEARCH, 1997, 25 (06) :1317-1318
[8]   Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces [J].
Rubtsov, Yuri P. ;
Rasmussen, Jeffrey P. ;
Chi, Emil Y. ;
Fontenot, Jason ;
Castelli, Luca ;
Ye, Xin ;
Treuting, Piper ;
Siewe, Lisa ;
Roers, Axel ;
Henderson, William R., Jr. ;
Muller, Werner ;
Rudensky, Alexander Y. .
IMMUNITY, 2008, 28 (04) :546-558
[9]   Vagaries of conditional gene targeting [J].
Schmidt-Supprian, Marc ;
Rajewsky, Klaus .
NATURE IMMUNOLOGY, 2007, 8 (07) :665-668
[10]   Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression [J].
Wan, Yisong Y. ;
Flavell, Richard A. .
NATURE, 2007, 445 (7129) :766-770