Role of Helicobacter pylori in gastric carcinogenesis

被引：53
作者：
Sepulveda, AR
Graham, DY
机构：
[1] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA
[2] Vet Affairs Med Ctr, Digest Dis Sect, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
来源：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2002年 / 31卷 / 02期
关键词：
D O I：
10.1016/S0889-8553(02)00012-2
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Peptic ulcers and gastric malignancies are the two major complication of the course of Helicobacter pylori-associated chronic gastritis. Both gastric adenocarcinomas and MALT lymphomas occur in association with H. pylori infection, and studies support an etiological association. This article discusses the natural history of H. pylori-related gastric carcinogenesis and criteria to identify people susceptible to H. pylori infection-associated gastric cancer. It then reviews the molecular and genetic mechanisms underlying the malignant transformation of the gastric mucosa associated with H. pylori.
引用
收藏
页码：517 / +
页数：20
相关论文
共 128 条
[1]  
*AM CANC SOC, 2000, EST NEW CANC CAS DEA
[2]  
[Anonymous], 1994, IARC Monogr Eval Carcinog Risks Hum, V61, P1
[3]  
Arzimanoglou II, 1998, CANCER-AM CANCER SOC, V82, P1808, DOI 10.1002/(SICI)1097-0142(19980515)82:10<1808::AID-CNCR2>3.0.CO
[4]  
2-J
[5]   Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells [J].
Asahi, M ;
Azuma, T ;
Ito, S ;
Ito, Y ;
Suto, H ;
Nagai, Y ;
Tsubokawa, M ;
Tohyama, Y ;
Maeda, S ;
Omata, M ;
Suzuki, T ;
Sasakawa, C .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (04) :593-602
[6]  
Bazzoli F, 2000, HELICOBACTER, V5, pS27
[7]  
Brenner H, 2000, CANCER, V88, P274, DOI 10.1002/(SICI)1097-0142(20000115)88:2<274::AID-CNCR5>3.0.CO
[8]  
2-9
[9]   Inhibition of gastric mucin synthesis by Helicobacter pylori [J].
Byrd, JC ;
Yunker, CK ;
Xu, QS ;
Sternberg, LR ;
Bresalier, RS .
GASTROENTEROLOGY, 2000, 118 (06) :1072-+
[10]   Topographic patterns of intestinal metaplasia and gastric cancer [J].
Cassaro, M ;
Rugge, M ;
Gutierrez, O ;
Leandro, G ;
Graham, DY ;
Genta, RM .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2000, 95 (06) :1431-1438
12345678910