Transformation from atypical chronic myeloid leukemia to chronic myelomonocytic leukemia as progression of myeloid neoplasm with platelet-derived growth factor β rearrangement

被引：0
作者：
Shi, Xue [1 ]
Su, Zhan [1 ]
Zhao, Chunting [1 ]
Feng, Xianqi [1 ]
机构：
[1] Affiliated Hosp Qingdao Univ, Dept Haematol, Qingdao 266003, Peoples R China
来源：
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2015年 / 11卷 / 04期
关键词：
Morphology; myeloid neoplasm; platelet-derived growth factor beta; transformation; CLASSIFICATION; SYSTEMS; DISEASE;
D O I：
10.4103/0973-1482.160922
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Myeloid neoplasms associated with platelet-derived growth factor b (PDGFRB) rearrangement usually keep only one morphologic type unless blast crisis. We describe a unique case of hematological features transformation from atypical chronic myeloid leukemia to chronic myelomonocytic leukemia, and imatinib showed no clinical therapeutic effects. The phenomenon indicates that different types of myeloid neoplasms associated with PDGFRB rearrangement can transform into one another with the progression of the disease, and to some extent, this transformation suggests the aggravation of disease.
引用
收藏
页码：914 / 916
页数：3
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