Genetic variants in microRNAs are associated with cervical cancer risk

被引:23
作者
Wang, Shizhi [1 ]
Zhu, Haixia [2 ]
Ding, Bo [3 ]
Feng, Xinrui [1 ]
Zhao, Wenxuan [1 ]
Cui, Mengjing [1 ]
Xu, Yuling [1 ]
Shi, Minxin [4 ]
Chen, Jian [2 ]
Jin, Hua [2 ]
机构
[1] Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med Engn, Nanjing, Jiangsu, Peoples R China
[2] Nantong Univ, Nantong Tumor Hosp, Affiliated Tumor Hosp, Clin Lab, Nantong, Peoples R China
[3] Southeast Univ, Sch Med, Zhongda Hosp, Dept Gynecol & Obstet, Nanjing, Jiangsu, Peoples R China
[4] Nantong Univ, Nantong Tumor Hosp, Affiliated Tumor Hosp, Dept Surg, Nantong, Peoples R China
关键词
GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; BLADDER-CANCER; POLYMORPHISMS; EXPRESSION; MIR-149; PROLIFERATION; RS2292832; RS895819;
D O I
10.1093/mutage/gez005
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Because genetic variants in microRNAs (miRNAs) or their surrounding regions can alter miRNA processing, expression and final biological function, we investigated whether miRNA single-nucleotide polymorphisms (SNPs) are associated with cervical cancer (CC) susceptibility. Common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, miR-499 rs3746444, miR-605 rs2043556 and miR-618 rs2682818) were genotyped in the 954 patients and 1339 controls. The results showed that the miR-149 rs2292832 TC/CC genotypes were associated with a 21% increased risk of CC compared with the TT genotype [odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.00-1.47]. The association was more prominent among the subjects with age <= 48 years (OR = 1.55, 95% CI = 1.16-2.06), having history of abortion (OR = 1.44, 95% CI = 1.12-1.86), premenopausal status (OR = 1.41, 95% CI = 1.08-1.85) and patients with clinical stage II of CC (OR = 1.43, 95% CI = 1.08-1.90). The expression plasmids containing the pre-miR-149 sequence with C allele of rs2292832 transcribed higher amount of mature miR-149-5p/3p than these with T allele in the HeLa and SiHa cells. Therefore, the rs2292832 polymorphism might influence CC susceptibility through modulation of the procession of pre-miR-149 to mature miRNAs.
引用
收藏
页码:127 / 133
页数:7
相关论文
共 39 条
[1]   Cell-autonomous and cell non-autonomous downregulation of tumor suppressor DAB2IP by microRNA-149-3p promotes aggressiveness of cancer cells [J].
Bellazzo, Arianna ;
Di Minin, Giulio ;
Valentino, Elena ;
Sicari, Dania ;
Torre, Denis ;
Marchionni, Luigi ;
Serpi, Federica ;
Stadler, Michael B. ;
Taverna, Daniela ;
Zuccolotto, Gaia ;
Montagner, Isabella Monia ;
Rosato, Antonio ;
Tonon, Federica ;
Zennaro, Cristina ;
Agostinis, Chiara ;
Bulla, Roberta ;
Mano, Miguel ;
Del Sal, Giannino ;
Collavin, Licio .
CELL DEATH AND DIFFERENTIATION, 2018, 25 (07) :1224-1238
[2]   Genome-wide Association Study of Susceptibility Loci for Cervical Cancer [J].
Chen, Dan ;
Juko-Pecirep, Ivana ;
Hammer, Joanna ;
Ivansson, Emma ;
Enroth, Stefan ;
Gustavsson, Inger ;
Feuk, Lars ;
Magnusson, Patrik K. E. ;
McKay, James D. ;
Wilander, Erik ;
Gyllensten, Ulf .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2013, 105 (09) :624-633
[3]   Annual report on status of cancer in China, 2011 [J].
Chen, Wanqing ;
Zheng, Rongshou ;
Zeng, Hongmei ;
Zhang, Siwei ;
He, Jie .
CHINESE JOURNAL OF CANCER RESEARCH, 2015, 27 (01) :2-12
[4]   Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population [J].
Chen, Yuetong ;
Du, Mulong ;
Chen, Wei ;
Zhu, Lingjun ;
Wu, Congye ;
Zhang, Zhengdong ;
Wang, Meilin ;
Chu, Haiyan ;
Gu, Dongying ;
Chen, Jinfei .
CANCER MEDICINE, 2018, 7 (04) :1194-1200
[5]   Five Common Functional Polymorphisms in microRNAs (rs2910164, rs2292832, rs11614913, rs3746444, rs895819) and the Susceptibility to Breast Cancer: Evidence from 8361 Cancer Cases and 8504 Controls [J].
Dai, Zhi-Jun ;
Shao, Yong-Ping ;
Wang, Xi-Jing ;
Xu, Dan ;
Kang, Hua-Feng ;
Ren, Hong-Tao ;
Min, Wei-Li ;
Lin, Shuai ;
Wang, Meng ;
Song, Zhang-Jun .
CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (11) :1455-1463
[6]   Susceptibility to cervical cancer: An overview [J].
de Freitas, Antonio Carlos ;
Almeida Diniz Gurgel, Ana Pavla ;
Chagas, Barbara Simas ;
Coimbra, Eliane Campos ;
Medeiros do Amaral, Carolina Maria .
GYNECOLOGIC ONCOLOGY, 2012, 126 (02) :304-311
[7]   Systematic evaluation of cancer risk associated with rs2292832 in miR-149 and rs895819 in miR-27a: a comprehensive and updated meta-analysis [J].
Feng, Yajing ;
Duan, Fujiao ;
Song, Chunhua ;
Zhao, Xia ;
Dai, Liping ;
Cui, Shuli .
ONCOTARGET, 2016, 7 (16) :22368-22384
[8]   Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 [J].
Ferlay, Jacques ;
Soerjomataram, Isabelle ;
Dikshit, Rajesh ;
Eser, Sultan ;
Mathers, Colin ;
Rebelo, Marise ;
Parkin, Donald Maxwell ;
Forman, David ;
Bray, Freddie .
INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) :E359-E386
[9]   Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis [J].
Fu, Alan ;
Hoffman, Aaron E. ;
Liu, Ran ;
Jacobs, Daniel I. ;
Zheng, Tongzhang ;
Zhu, Yong .
EPIGENETICS, 2014, 9 (05) :730-737
[10]  
Garzon R, 2009, ANNU REV MED, V60, P167, DOI [10.1146/annurev.med.59.053006.104707, 10.1146/annurev.pathol.4.110807.092222]