Radical-mediated three-component coupling of alkenes

被引：20

作者：

Schaffner, Arnaud Pierre ^{[1
]}

Sarkunam, Kandhasamy ^{[1
]}

Renaud, Philippe ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2006年 / 89卷 / 10期

关键词：

D O I：

10.1002/hlca.200690225

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A tandem radical process involving conjugate addition to an activated alkene followed by allylation is reported. B-Alkylcatecholboranes, easily available via hydroboration of the corresponding alkenes, were used to generate the initial radicals. These radicals add efficiently to electrophilic alkenes such as phenyl vinyl sulfone, N-phenylmaleimide, and dialkyl fumarate. In the last step of this one-pot process, the radical adducts react with the allylic sulfones. ne whole process can be considered as a unique and selective coupling of three different alkenes.

引用

页码：2450 / 2461

页数：12

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